Endocrine Abstracts

Introduction: Primary endocrine failure in β-Thal is caused by iron overload in epithelial cells and in interstitial macrophages. Autoimmune phenomena are not believed to play any significant role, although iron overload, through non-specific inflammatory process, could trigger autoimmunity, as recently suggested for the pathogenesis of diabetes mellitus in β-Thal patients.Purpose: We investigated thyroid function and anti-thyroid autoantibodie...

Introduction: To date, two pharmacogenetic studies investigated the effect of the common exon 3 deletion of GH receptor (d3-GHR) variant in small series of acromegalic patients treated with Pegvisomant (Peg), suggesting an association of d3-GHR allele with better response to Peg.Aim: To assess the influence of d3-GHR variant in a large cohort of acromegalics with active disease and resistance to somatostatin analogues (SSA) treated with either Peg monoth...